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BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.
Bery, Nicolas; Cruz-Migoni, Abimael; Bataille, Carole Jr; Quevedo, Camilo E; Tulmin, Hanna; Miller, Ami; Russell, Angela; Phillips, Simon Ev; Carr, Stephen B; Rabbitts, Terence H.
Affiliation
  • Bery N; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
  • Cruz-Migoni A; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
  • Bataille CJ; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom.
  • Quevedo CE; Chemistry Research Laboratory, Oxford, United Kingdom.
  • Tulmin H; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
  • Miller A; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
  • Russell A; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
  • Phillips SE; Chemistry Research Laboratory, Oxford, United Kingdom.
  • Carr SB; Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
  • Rabbitts TH; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom.
Elife ; 72018 07 10.
Article in En | MEDLINE | ID: mdl-29989546
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biosensing Techniques / Proto-Oncogene Proteins p21(ras) / Small Molecule Libraries / Protein Interaction Domains and Motifs / Bioluminescence Resonance Energy Transfer Techniques / Mutation Limits: Humans Language: En Journal: Elife Year: 2018 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biosensing Techniques / Proto-Oncogene Proteins p21(ras) / Small Molecule Libraries / Protein Interaction Domains and Motifs / Bioluminescence Resonance Energy Transfer Techniques / Mutation Limits: Humans Language: En Journal: Elife Year: 2018 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom