Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction.

Alex, Linda; Russo, Ilaria; Holoborodko, Volodymir; Frangogiannis, Nikolaos G

Alex, Linda; Russo, Ilaria; Holoborodko, Volodymir; Frangogiannis, Nikolaos G.

Affiliation

Alex L; Department of Medicine (Cardiology), The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York.
Russo I; Department of Medicine (Cardiology), The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York.
Holoborodko V; Department of Medicine (Cardiology), The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York.
Frangogiannis NG; Department of Medicine (Cardiology), The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York.

Am J Physiol Heart Circ Physiol ; 315(4): H934-H949, 2018 10 01.

Article in En | MEDLINE | ID: mdl-30004258

Subject(s)

Cardiomyopathies/etiology; Heart Failure/etiology; Heart Ventricles/physiopathology; Obesity/complications; Stroke Volume; Ventricular Function, Left; Ventricular Remodeling; Adiposity; Animals; Cardiomyopathies/metabolism; Cardiomyopathies/pathology; Cardiomyopathies/physiopathology; Cells, Cultured; Disease Models, Animal; Echocardiography, Doppler; Extracellular Matrix/metabolism; Extracellular Matrix/pathology; Extracellular Matrix Proteins/metabolism; Female; Fibroblasts/metabolism; Fibroblasts/pathology; Fibrosis; Heart Failure/metabolism; Heart Failure/pathology; Heart Failure/physiopathology; Heart Ventricles/metabolism; Heart Ventricles/pathology; Humans; Hypertension/etiology; Hypertension/physiopathology; Hypertrophy, Left Ventricular/etiology; Hypertrophy, Left Ventricular/physiopathology; Male; Mice, Inbred C57BL; Mice, Obese; Myocardium/metabolism; Myocardium/pathology; Obesity/genetics; Obesity/physiopathology; Sex Factors; Time Factors; Ventricular Dysfunction, Left/etiology; Ventricular Dysfunction, Left/physiopathology

Key words

diabetes; diastolic dysfunction; fibroblast; fibrosis; hypertrophy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stroke Volume / Ventricular Function, Left / Ventricular Remodeling / Heart Failure / Heart Ventricles / Cardiomyopathies / Obesity Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2018 Document type: Article Country of publication: United States

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