Glutathione peroxidase-1 overexpressing transgenic mice are protected from neurotoxicity induced by microcystin-leucine-arginine.

Shin, Eun-Joo; Hwang, Yeong Gwang; Pham, Duc Toan; Lee, Ji Won; Lee, Yu Jeung; Pyo, Dongjin; Jeong, Ji Hoon; Lei, Xin Gen; Kim, Hyoung-Chun

Shin, Eun-Joo; Hwang, Yeong Gwang; Pham, Duc Toan; Lee, Ji Won; Lee, Yu Jeung; Pyo, Dongjin; Jeong, Ji Hoon; Lei, Xin Gen; Kim, Hyoung-Chun.

Affiliation

Shin EJ; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea.
Hwang YG; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea.
Pham DT; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea.
Lee JW; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea.
Lee YJ; Clinical Pharmacy, College of Pharmacy, Kangwon National University, Republic of Korea.
Pyo D; Department of Chemistry, College of Natural Sciences, Kangwon National University, Republic of Korea.
Jeong JH; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Lei XG; Department of Animal Science, Cornell University, New York.
Kim HC; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea.

Environ Toxicol ; 33(10): 1019-1028, 2018 Oct.

Article in En | MEDLINE | ID: mdl-30076769

Subject(s)

Arginine/toxicity; Glutathione Peroxidase/metabolism; Hippocampus/drug effects; Leucine/toxicity; Microcystins/toxicity; Aldehydes/analysis; Animals; Down-Regulation/drug effects; Glutathione/metabolism; Glutathione Peroxidase/genetics; Hippocampus/metabolism; Hippocampus/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B/antagonists & inhibitors; NF-kappa B/metabolism; Oxidative Stress/drug effects; Protein Carbonylation/drug effects; Pyrrolidines/pharmacology; Reactive Oxygen Species/metabolism; Superoxide Dismutase-1/metabolism; Thiocarbamates/pharmacology; Up-Regulation/drug effects; Glutathione Peroxidase GPX1

Key words

GPx-1 overexpressing transgenic mice; NFκB; hippocampus; intracerebroventricular infusion; microcystin-leucine-arginine; neurotoxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Microcystins / Glutathione Peroxidase / Hippocampus / Leucine Limits: Animals Language: En Journal: Environ Toxicol Journal subject: SAUDE AMBIENTAL / TOXICOLOGIA Year: 2018 Document type: Article

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