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Seven new resin glycosides from the seeds of Quamoclit × multifida.
Ono, Masateru; Azuchi, Maako; Ichio, Misato; Jiyoubi, Yuki; Tsutsumi, Shuhei; Yasuda, Shin; Tsuchihasi, Ryota; Okawa, Masafumi; Kinjo, Junei; Yoshimitsu, Hitoshi; Nohara, Toshihiro.
Affiliation
  • Ono M; School of Agriculture, Tokai University, 9-1-1 Toroku, Higashi-ku, Kumamoto, 862-8652, Japan. mono@agri.u-tokai.ac.jp.
  • Azuchi M; School of Agriculture, Tokai University, 9-1-1 Toroku, Higashi-ku, Kumamoto, 862-8652, Japan.
  • Ichio M; School of Agriculture, Tokai University, 9-1-1 Toroku, Higashi-ku, Kumamoto, 862-8652, Japan.
  • Jiyoubi Y; School of Agriculture, Tokai University, 9-1-1 Toroku, Higashi-ku, Kumamoto, 862-8652, Japan.
  • Tsutsumi S; School of Agriculture, Tokai University, 9-1-1 Toroku, Higashi-ku, Kumamoto, 862-8652, Japan.
  • Yasuda S; School of Agriculture, Tokai University, 9-1-1 Toroku, Higashi-ku, Kumamoto, 862-8652, Japan.
  • Tsuchihasi R; Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
  • Okawa M; Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
  • Kinjo J; Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
  • Yoshimitsu H; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-2 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan.
  • Nohara T; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-2 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan.
J Nat Med ; 73(1): 11-22, 2019 Jan.
Article in En | MEDLINE | ID: mdl-30097766
Seven new resin glycosides, multifidins III (1)-IX (7), were isolated from the seeds of Quamoclit × multifida (syn. Q. sloteri House) (Convolvulaceae), along with five known glycosides, quamoclinic acid B methyl ester (8), operculin XIII (9), quamoclin I (10), QM-10 (11), and QM-12 (12). Their structures were determined on the basis of spectroscopic data and chemical evidence. These compounds were of two different types, i.e., those with macrolactone structures and those with non-macrolactone structures. Additionally, cytotoxic activity towards HL-60 human leukemia cells of 1, 2, 5, 8, 9, 11, and 12 was evaluated. Among them, macrolactone-type resin glycosides (jalapins), 1, 2, and 9, specifically demonstrated clear cytotoxic activity with IC50 values of 3.46, 14.7, and 10.9 µM, respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Resins, Plant / Seeds / Glycosides Limits: Humans Language: En Journal: J Nat Med Journal subject: TERAPIAS COMPLEMENTARES Year: 2019 Document type: Article Affiliation country: Japan Country of publication: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Resins, Plant / Seeds / Glycosides Limits: Humans Language: En Journal: J Nat Med Journal subject: TERAPIAS COMPLEMENTARES Year: 2019 Document type: Article Affiliation country: Japan Country of publication: Japan