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Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246.
Haffo, Lena; Lu, Jun; Bykov, Vladimir J N; Martin, Sebastin S; Ren, Xiaoyuan; Coppo, Lucia; Wiman, Klas G; Holmgren, Arne.
Affiliation
  • Haffo L; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
  • Lu J; Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Bykov VJN; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
  • Martin SS; School of Pharmaceutical Sciences, Southwest University, 400715, Chongqing, China.
  • Ren X; Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Coppo L; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
  • Wiman KG; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
  • Holmgren A; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
Sci Rep ; 8(1): 12671, 2018 08 23.
Article in En | MEDLINE | ID: mdl-30140002
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioredoxins / Glutaredoxins Limits: Humans Language: En Journal: Sci Rep Year: 2018 Document type: Article Affiliation country: Sweden
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioredoxins / Glutaredoxins Limits: Humans Language: En Journal: Sci Rep Year: 2018 Document type: Article Affiliation country: Sweden