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High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis.
Xu, Xingbo; Tan, Xiaoying; Tampe, Björn; Wilhelmi, Tim; Hulshoff, Melanie S; Saito, Shoji; Moser, Tobias; Kalluri, Raghu; Hasenfuss, Gerd; Zeisberg, Elisabeth M; Zeisberg, Michael.
Affiliation
  • Xu X; Department of Cardiology and Pneumology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
  • Tan X; German Center for Cardiovascular Research (DZHK) Partner Site, Göttingen, Germany.
  • Tampe B; German Center for Cardiovascular Research (DZHK) Partner Site, Göttingen, Germany.
  • Wilhelmi T; Department of Nephrology and Rheumatology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
  • Hulshoff MS; Department of Nephrology and Rheumatology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
  • Saito S; Department of Cardiology and Pneumology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
  • Moser T; German Center for Cardiovascular Research (DZHK) Partner Site, Göttingen, Germany.
  • Kalluri R; Department of Cardiology and Pneumology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
  • Hasenfuss G; German Center for Cardiovascular Research (DZHK) Partner Site, Göttingen, Germany.
  • Zeisberg EM; Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713, Groningen, GZ, Netherlands.
  • Zeisberg M; Department of Nephrology and Rheumatology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
Nat Commun ; 9(1): 3509, 2018 08 29.
Article in En | MEDLINE | ID: mdl-30158531
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fibrosis / DNA Methylation / CRISPR-Cas Systems / Kidney Diseases Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Document type: Article Affiliation country: Germany Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fibrosis / DNA Methylation / CRISPR-Cas Systems / Kidney Diseases Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Document type: Article Affiliation country: Germany Country of publication: United kingdom