Endogenous Omega (n)-3 Fatty Acids in Fat-1 Mice Attenuated Depression-Like Behavior, Imbalance between Microglial M1 and M2 Phenotypes, and Dysfunction of Neurotrophins Induced by Lipopolysaccharide Administration.

Gu, Minqing; Li, Yuyu; Tang, Haiting; Zhang, Cai; Li, Wende; Zhang, Yongping; Li, Yajuan; Zhao, Yuntao; Song, Cai

Gu, Minqing; Li, Yuyu; Tang, Haiting; Zhang, Cai; Li, Wende; Zhang, Yongping; Li, Yajuan; Zhao, Yuntao; Song, Cai.

Affiliation

Gu M; Research Institute for Marine Drug and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China. guminqingwawa@163.com.
Li Y; Research Institute for Marine Drug and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China. YUYULI2016@163.com.
Tang H; Research Institute for Marine Drug and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China. THT19118@126.com.
Zhang C; Research Institute for Marine Drug and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China. zhangcai910206@163.com.
Li W; Shenzhen Institute of Guangdong Ocean University, Shenzhen 518120, China. zhangcai910206@163.com.
Zhang Y; Guangdong Key Laboratory for Research and Development of Natural Drug, Guangdong Medical College, Zhanjiang 524023, China. lwd@gdlami.com.
Li Y; Guangdong Key laboratory of Laboratory Animal, Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510663, China. lwd@gdlami.com.
Zhao Y; Research Institute for Marine Drug and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China. zhangyp2015@163.com.
Song C; Shenzhen Institute of Guangdong Ocean University, Shenzhen 518120, China. zhangyp2015@163.com.

Nutrients ; 10(10)2018 Sep 21.

Article in En | MEDLINE | ID: mdl-30248907

Subject(s)

Brain-Derived Neurotrophic Factor/metabolism; Brain/metabolism; CD11b Antigen; Depression/metabolism; Fatty Acids, Omega-3/metabolism; Inflammation/metabolism; Microglia/metabolism; Animals; Behavior, Animal/drug effects; Behavior, Animal/physiology; Brain/drug effects; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Cytokines/metabolism; Depression/etiology; Depressive Disorder/metabolism; Diet; Fatty Acid Desaturases/genetics; Fatty Acid Desaturases/metabolism; Fatty Acids, Omega-3/pharmacology; Fatty Acids, Omega-6/metabolism; Glial Fibrillary Acidic Protein/metabolism; Hindlimb Suspension; Inflammation/chemically induced; Inflammation/complications; Lipopolysaccharides; Membrane Glycoproteins/metabolism; Mice, Inbred C57BL; Mice, Transgenic; Microglia/drug effects; Nerve Growth Factors/metabolism; Phenotype; Protein-Tyrosine Kinases/metabolism; Swimming

Key words

BDNF; Fat-1 transgenic mice; depression; microglial M1 and M2 phenotypes; n-3 fatty acids; neurotrophins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Fatty Acids, Omega-3 / Microglia / Brain-Derived Neurotrophic Factor / CD11b Antigen / Depression / Inflammation Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Nutrients Year: 2018 Document type: Article Affiliation country: China

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