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CKD-MBD: from the Pathogenesis to the Identification and Development of Potential Novel Therapeutic Targets.
Elias, Rosilene Motta; Dalboni, Maria Aparecida; Coelho, Ana Carolina E; Moysés, Rosa M A.
Affiliation
  • Elias RM; Universidade Nove de Julho, UNINOVE, Rua Iperoig, 690 ap 121, São Paulo, SP, 05016-000, Brazil.
  • Dalboni MA; Nephrology Division, HCFCMUSP, Universidade de São Paulo, São Paulo, Brazil.
  • Coelho ACE; Universidade Nove de Julho, UNINOVE, Rua Iperoig, 690 ap 121, São Paulo, SP, 05016-000, Brazil.
  • Moysés RMA; Nephrology Division, Universidade Estadual Paulista, UNESP, São Paulo, Brazil.
Curr Osteoporos Rep ; 16(6): 693-702, 2018 12.
Article in En | MEDLINE | ID: mdl-30291515
PURPOSE OF REVIEW: Although we have seen tremendous advances in the comprehension of CKD-MBD pathophysiology during the last few years, this was not accompanied by a significant change in mortality rate and quality of life. This review will address the traditional and updated pathophysiology of CKD-MBD along with the therapeutic limitations that affect CKD-MBD and proposed alternative treatment targets. RECENT FINDINGS: An innovative concept brings the osteocyte to the center of CKD-MBD pathophysiology, in contrast to the traditional view of the skeleton as a target organ for disturbances in calcium, phosphate, parathyroid hormone, and vitamin D. Osteocytes, through the synthesis of FGF-23, sclerostin, among others, are able to interact with other organs, making bone an endocrine organ. Thus, osteocyte dysregulation might be an early event during the course of CKD. This review will revisit general concepts on the pathophysiology of CKD-MBD and discuss new perspectives for its treatment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chronic Kidney Disease-Mineral and Bone Disorder / Disease Management / Hyperparathyroidism, Secondary Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Aspects: Patient_preference Limits: Animals / Humans Language: En Journal: Curr Osteoporos Rep Journal subject: ORTOPEDIA Year: 2018 Document type: Article Affiliation country: Brazil Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chronic Kidney Disease-Mineral and Bone Disorder / Disease Management / Hyperparathyroidism, Secondary Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Aspects: Patient_preference Limits: Animals / Humans Language: En Journal: Curr Osteoporos Rep Journal subject: ORTOPEDIA Year: 2018 Document type: Article Affiliation country: Brazil Country of publication: United States