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Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes.
Ashraf, Adnan; Ejaz, Syeda Abida; Rahman, Shafiq Ur; Siddiqui, Waseeq Ahmad; Arshad, Muhammad Nadeem; Lecka, Joanna; Sévigny, Jean; Zayed, Mohie E Moustafa; Asiri, Abdullah M; Iqbal, Jamshed; Hartinger, Christian G; Hanif, Muhammad.
Affiliation
  • Ashraf A; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand; Department of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan.
  • Ejaz SA; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad-22060, Pakistan.
  • Rahman SU; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad-22060, Pakistan.
  • Siddiqui WA; Department of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan. Electronic address: waseeq.ahmad@uos.edu.pk.
  • Arshad MN; Department of Chemistry, Faculty of Science, King Abdul Aziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia; Center of Excellence for Advanced Materials Research (CEAMR), King Abdul Aziz University, P.O.Box 80203, Jeddah, 21589, Saudi Arabia.
  • Lecka J; Département de Microbiologie-Infectiologie et d'Immunologie, Faculté de Médecine, Université Laval, Québec, QC, G1V 0A6, Canada; Centre de Recherche du CHU de Québec - Université Laval, Québec, QC, G1V 4G2, Canada.
  • Sévigny J; Département de Microbiologie-Infectiologie et d'Immunologie, Faculté de Médecine, Université Laval, Québec, QC, G1V 0A6, Canada; Centre de Recherche du CHU de Québec - Université Laval, Québec, QC, G1V 4G2, Canada.
  • Zayed MEM; Department of Chemistry, Faculty of Science, King Abdul Aziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia.
  • Asiri AM; Department of Chemistry, Faculty of Science, King Abdul Aziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia; Center of Excellence for Advanced Materials Research (CEAMR), King Abdul Aziz University, P.O.Box 80203, Jeddah, 21589, Saudi Arabia.
  • Iqbal J; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad-22060, Pakistan.
  • Hartinger CG; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
  • Hanif M; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. Electronic address: m.hanif@auckland.ac.nz.
Eur J Med Chem ; 159: 282-291, 2018 Nov 05.
Article in En | MEDLINE | ID: mdl-30296687

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiazines / Chalcone / Alkaline Phosphatase / Enzyme Inhibitors / Inhibitor of Apoptosis Proteins Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2018 Document type: Article Affiliation country: Pakistan Country of publication: France

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiazines / Chalcone / Alkaline Phosphatase / Enzyme Inhibitors / Inhibitor of Apoptosis Proteins Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2018 Document type: Article Affiliation country: Pakistan Country of publication: France