Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro.

Horn, Gabriele; de Koning, Martijn Constantijn; van Grol, Marco; Thiermann, Horst; Worek, Franz

Horn, Gabriele; de Koning, Martijn Constantijn; van Grol, Marco; Thiermann, Horst; Worek, Franz.

Affiliation

Horn G; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany.
de Koning MC; TNO, Lange Kleiweg 137, 2288 GJ Rijswijk, the Netherlands.
van Grol M; TNO, Lange Kleiweg 137, 2288 GJ Rijswijk, the Netherlands.
Thiermann H; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany.
Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany. Electronic address: franzworek@bundeswehr.org.

Toxicol Lett ; 299: 218-225, 2018 Dec 15.

Article in En | MEDLINE | ID: mdl-30312685

Subject(s)

Acetylcholinesterase/metabolism; Cholinesterase Inhibitors/toxicity; Cholinesterase Reactivators/pharmacology; Organophosphorus Compounds/toxicity; Phenols/pharmacology; Animals; Cholinesterase Reactivators/chemistry; Erythrocyte Membrane/drug effects; Erythrocyte Membrane/enzymology; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Phenols/chemistry; Structure-Activity Relationship

Key words

Acetylcholinesterase; In vitro; Non-oxime reactivator; Organophosphorus compounds; Reactivation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organophosphorus Compounds / Phenols / Acetylcholinesterase / Cholinesterase Inhibitors / Cholinesterase Reactivators Limits: Animals / Humans Language: En Journal: Toxicol Lett Year: 2018 Document type: Article Affiliation country: Germany Country of publication: Netherlands

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