Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-ß1.

Zhang, Xia; Zhang, Ming-Chao; Wang, Chun-Tian

Zhang, Xia; Zhang, Ming-Chao; Wang, Chun-Tian.

Affiliation

Zhang X; Department of Cardiology, Wuhu Traditional Chinese Hospital, Wuhu, 241000, China. Electronic address: 3339867505@qq.com.
Zhang MC; Department of Cardiology, Second Affiliated Hospital of Wannan Medical College, Wuhu, 241000, China.
Wang CT; Department of Cardiology, Huainan First People's Hospital, Huainan, 232000, China.

Biochem Biophys Res Commun ; 506(1): 137-144, 2018 11 17.

Article in En | MEDLINE | ID: mdl-30340835

Subject(s)

Cardiomegaly/pathology; Fibrosis/etiology; Inflammation/etiology; Membrane Proteins/physiology; Transforming Growth Factor beta1/pharmacology; Animals; Cardiomegaly/etiology; Fibrosis/chemically induced; Gene Knockout Techniques; Humans; In Vitro Techniques; Inflammation/chemically induced; Membrane Proteins/deficiency; Membrane Proteins/genetics; Mice; Myocytes, Cardiac/metabolism; NF-kappa B/metabolism; NF-kappa B/pharmacology; Transforming Growth Factor beta1/metabolism

Key words

Cardiac hypertrophy; Fibrosis and inflammation; LRRC25; NF-κB; TGF-ß1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fibrosis / Cardiomegaly / Transforming Growth Factor beta1 / Inflammation / Membrane Proteins Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Biophys Res Commun Year: 2018 Document type: Article Country of publication: United States

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