Clonality assessment of multifocal lung adenocarcinoma by pathology evaluation and molecular analysis.

Sun, Wei; Feng, Lin; Yang, Xin; Li, Lin; Liu, Yu; Lv, Ning; Lin, Dongmei

Sun, Wei; Feng, Lin; Yang, Xin; Li, Lin; Liu, Yu; Lv, Ning; Lin, Dongmei.

Affiliation

Sun W; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, 100142 Beijing, China; Department of Pathology, Cancer Institute and Hospital, Peking Union Medical College, Chinese Academy of Medical Sci
Feng L; Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100021 Beijing, China.
Yang X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, 100142 Beijing, China.
Li L; Department of Pathology, Cancer Institute and Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100021 Beijing, China.
Liu Y; Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100021 Beijing, China.
Lv N; Department of Pathology, Cancer Institute and Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100021 Beijing, China. Electronic address: nlu03@126.com.
Lin D; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, 100142 Beijing, China. Electronic address: Lindm3@163.com.

Hum Pathol ; 81: 261-271, 2018 11.

Article in En | MEDLINE | ID: mdl-30420048

Subject(s)

Adenocarcinoma of Lung/diagnosis; Biomarkers, Tumor/genetics; Lung Neoplasms/diagnosis; Molecular Diagnostic Techniques; Mutation; Neoplasms, Multiple Primary/diagnosis; Proto-Oncogene Proteins p21(ras)/genetics; Adenocarcinoma of Lung/genetics; Adenocarcinoma of Lung/pathology; Adenocarcinoma of Lung/surgery; Adult; Aged; Biopsy; Comparative Genomic Hybridization; DNA Mutational Analysis; Diagnosis, Differential; Disease-Free Survival; ErbB Receptors/genetics; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms/genetics; Lung Neoplasms/secondary; Lung Neoplasms/surgery; Male; Middle Aged; Neoplasm Grading; Neoplasms, Multiple Primary/genetics; Neoplasms, Multiple Primary/pathology; Neoplasms, Multiple Primary/surgery; Phenotype; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors

Key words

Copy number variation; Epidermal growth factor receptor; Lepidic lesion; Multifocal lung adenocarcinoma; Pulmonary metastases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Proto-Oncogene Proteins p21(ras) / Molecular Diagnostic Techniques / Adenocarcinoma of Lung / Lung Neoplasms / Mutation / Neoplasms, Multiple Primary Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Hum Pathol Journal subject: PATOLOGIA Year: 2018 Document type: Article Country of publication: United States

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