Hypoxia accelerates intraplaque neovascularization derived from endothelial progenitor cells in carotid stenosis.

Kashiwazaki, Daina; Koh, Masaki; Uchino, Haruto; Akioka, Naoki; Kuwayama, Naoya; Noguchi, Kyo; Kuroda, Satoshi

Kashiwazaki, Daina; Koh, Masaki; Uchino, Haruto; Akioka, Naoki; Kuwayama, Naoya; Noguchi, Kyo; Kuroda, Satoshi.

Affiliation

Kashiwazaki D; Departments of1Neurosurgery and.
Koh M; Departments of1Neurosurgery and.
Uchino H; Departments of1Neurosurgery and.
Akioka N; Departments of1Neurosurgery and.
Kuwayama N; Departments of1Neurosurgery and.
Noguchi K; 2Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Kuroda S; Departments of1Neurosurgery and.

J Neurosurg ; 131(3): 884-891, 2018 10 05.

Article in En | MEDLINE | ID: mdl-30485214

Subject(s)

Carotid Stenosis/metabolism; Endothelial Progenitor Cells/physiology; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Hypoxia/complications; Neovascularization, Pathologic/complications; Plaque, Atherosclerotic/metabolism; Aged; Aged, 80 and over; Antigens, CD/metabolism; Carotid Stenosis/etiology; Carotid Stenosis/pathology; Endarterectomy, Carotid; Female; Humans; Hypoxia/metabolism; Male; Neovascularization, Pathologic/metabolism; Plaque, Atherosclerotic/etiology; Plaque, Atherosclerotic/pathology; Vascular Endothelial Growth Factor Receptor-2/metabolism

Key words

AB = diaminobenzidine tetrahydrochloride; EPC = endothelial progenitor cell; HIF = hypoxia-inducible factor; IPH = intraplaque hemorrhage; TOF = time of flight; VEGF = vascular endothelial growth factor; VEGFR = VEGF receptor; carotid stenosis; endothelial progenitor cell; hypoxia; plaque; vascular disorders; vulnerability

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carotid Stenosis / Hypoxia-Inducible Factor 1, alpha Subunit / Plaque, Atherosclerotic / Endothelial Progenitor Cells / Hypoxia / Neovascularization, Pathologic Type of study: Etiology_studies Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: J Neurosurg Year: 2018 Document type: Article Country of publication: United States

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