Treadmill exercise restores high fat diet-induced disturbance of hippocampal neurogenesis through ß2-adrenergic receptor-dependent induction of thioredoxin-1 and brain-derived neurotrophic factor.

Han, Tae-Kyung; Leem, Yea-Hyun; Kim, Hee-Sun

Han, Tae-Kyung; Leem, Yea-Hyun; Kim, Hee-Sun.

Affiliation

Han TK; College of Art & Physical Education, Andong National University, Andong, Gyeongbuk, South Korea.
Leem YH; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.
Kim HS; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea; Department of Brain & Cognitive Sciences, Ewha Womans University, Seoul, South Korea. Electronic address: hskimp@ewha.ac.kr.

Brain Res ; 1707: 154-163, 2019 03 15.

Article in En | MEDLINE | ID: mdl-30496734

Subject(s)

Motor Activity/physiology; Physical Conditioning, Animal/physiology; Receptors, Adrenergic, beta-2/metabolism; Animals; Brain-Derived Neurotrophic Factor/metabolism; Cerebral Cortex/metabolism; Diet, High-Fat/adverse effects; Doublecortin Protein; Hippocampus/metabolism; Male; Memory/physiology; Memory Disorders/metabolism; Mice; Mice, Inbred C57BL; Microglia/metabolism; Neurogenesis/physiology; Neuroprotective Agents/pharmacology; Physical Exertion/physiology; Temporal Lobe/metabolism; Thioredoxins/metabolism

Key words

High-fat diet; Hippocampal neurogenesis; Neuroinflammation; Regular exercise; Thioredoxin-1; ß2-Adrenergic receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Physical Conditioning, Animal / Receptors, Adrenergic, beta-2 / Motor Activity Limits: Animals Language: En Journal: Brain Res Year: 2019 Document type: Article Affiliation country: South Korea Country of publication: Netherlands

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