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Necrostatin-1 accelerates time to death in a rat model of cecal ligation and puncture and massively increases hepatocyte caspase-3 cleavage.
Zhang, Qin; Wei, Siwei; Lu, Jiayin; Fu, Weijun; Chen, Hui; Huang, Qiaobing; Chen, Zhongqing; Zeng, Zhenhua.
Affiliation
  • Zhang Q; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Peoples Republic of China.
  • Wei S; Guangdong Key Laboratory of Shock and Microcirculation Research, Department of Pathophysiology, Southern Medical University, Guangzhou, Peoples Republic of China.
  • Lu J; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Peoples Republic of China.
  • Fu W; Guangdong Key Laboratory of Shock and Microcirculation Research, Department of Pathophysiology, Southern Medical University, Guangzhou, Peoples Republic of China.
  • Chen H; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Peoples Republic of China.
  • Huang Q; Guangdong Key Laboratory of Shock and Microcirculation Research, Department of Pathophysiology, Southern Medical University, Guangzhou, Peoples Republic of China.
  • Chen Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Peoples Republic of China.
  • Zeng Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Peoples Republic of China.
Am J Physiol Gastrointest Liver Physiol ; 316(4): G551-G561, 2019 04 01.
Article in En | MEDLINE | ID: mdl-30735454
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Sepsis / Caspase 3 / Receptor-Interacting Protein Serine-Threonine Kinases / Necroptosis / Imidazoles / Indoles / Liver Diseases Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2019 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Sepsis / Caspase 3 / Receptor-Interacting Protein Serine-Threonine Kinases / Necroptosis / Imidazoles / Indoles / Liver Diseases Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2019 Document type: Article Country of publication: United States