Elevated expression of GNAS promotes breast cancer cell proliferation and migration via the PI3K/AKT/Snail1/E-cadherin axis.

Jin, X; Zhu, L; Cui, Z; Tang, J; Xie, M; Ren, G

Jin, X; Zhu, L; Cui, Z; Tang, J; Xie, M; Ren, G.

Affiliation

Jin X; Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuanjiagang, Yuzhong District, Chongqing, 400016, China.
Zhu L; Department of Breast Surgery, The First People's Hospital of Yibin, Yibin, Sichuan, China.
Cui Z; Department of Breast Surgery, The First People's Hospital of Yibin, Yibin, Sichuan, China.
Tang J; Department of Breast Surgery, The First People's Hospital of Yibin, Yibin, Sichuan, China.
Xie M; Department of Breast Surgery, The First People's Hospital of Yibin, Yibin, Sichuan, China.
Ren G; Department of Breast Surgery, The First People's Hospital of Yibin, Yibin, Sichuan, China.

Clin Transl Oncol ; 21(9): 1207-1219, 2019 Sep.

Article in En | MEDLINE | ID: mdl-30767161

Subject(s)

Biomarkers, Tumor/metabolism; Breast Neoplasms/pathology; Cell Movement; Cell Proliferation; Chromogranins/metabolism; GTP-Binding Protein alpha Subunits, Gs/metabolism; Gene Expression Regulation, Neoplastic; Animals; Antigens, CD/genetics; Antigens, CD/metabolism; Apoptosis; Biomarkers, Tumor/genetics; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Cadherins/genetics; Cadherins/metabolism; Chromogranins/genetics; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, Gs/genetics; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Prognosis; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction; Snail Family Transcription Factors/genetics; Snail Family Transcription Factors/metabolism; Survival Rate; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Key words

Breast cancer; Cell migration; Cell proliferation; GNAS; Metastasis; PI3K/AKT signaling

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Biomarkers, Tumor / Gene Expression Regulation, Neoplastic / Cell Movement / Chromogranins / GTP-Binding Protein alpha Subunits, Gs / Cell Proliferation Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Clin Transl Oncol Year: 2019 Document type: Article Affiliation country: China Country of publication: Italy

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google