[Antifibrotic effect of pirfenidone on orbital fibroblasts in patients with thyroid-associated ophthalmopathy and its mechanisms].

Li, D D; Liu, Y; Yuan, R R; Yu, T; Yang, B; Pang, W Y

Li, D D; Liu, Y; Yuan, R R; Yu, T; Yang, B; Pang, W Y.

Affiliation

Li DD; Department of Endocrinology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, China.
Liu Y; Department of Endocrinology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, China.
Yuan RR; Department of Endocrinology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, China.
Yu T; Department of Endocrinology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, China.
Yang B; Department of Ophthalmology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, China.
Pang WY; Department of Endocrinology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, China.

Zhonghua Nei Ke Za Zhi ; 58(3): 185-190, 2019 Mar 01.

Article in Zh | MEDLINE | ID: mdl-30803176

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Fibroblasts/drug effects; Graves Ophthalmopathy/metabolism; Pyridones/pharmacology; Transforming Growth Factor beta1/genetics; Cells, Cultured; Fibroblasts/metabolism; Graves Ophthalmopathy/pathology; Humans; Polymerase Chain Reaction; Pyridones/administration & dosage

Key words

Orbital fibroblast; Pirfenidone; Thyroid; Transforming growth factor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Anti-Inflammatory Agents, Non-Steroidal / Graves Ophthalmopathy / Transforming Growth Factor beta1 / Fibroblasts Type of study: Risk_factors_studies Limits: Humans Language: Zh Journal: Zhonghua Nei Ke Za Zhi Year: 2019 Document type: Article Affiliation country: China

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