Role of Trifluoromethyl Substitution in Design of Antimalarial Quinolones: a Comprehensive Review.

Romero, Angel H

Romero, Angel H.

Affiliation

Romero AH; Cátedra de Química General, Facultad de Farmacia, Universidad Central de Venezuela, Los Chaguaramos, Caracas, 1041-A, Venezuela. angel.ucv.usb@gmail.com.

Top Curr Chem (Cham) ; 377(2): 9, 2019 Mar 05.

Article in En | MEDLINE | ID: mdl-30835005

Subject(s)

Antimalarials/chemical synthesis; Drug Design; Hydrocarbons, Fluorinated/chemistry; Quinolones/chemical synthesis; Antimalarials/chemistry; Antimalarials/pharmacology; Hydrocarbons, Fluorinated/pharmacology; Malaria, Falciparum/drug therapy; Parasitic Sensitivity Tests; Plasmodium falciparum/drug effects; Quinolones/chemistry; Quinolones/pharmacology

Key words

Antimalarial; Chloroquine; ELQ; Plasmodium; Quinolone; Structureproperty relationship; Trifluoromethyl substitution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Quinolones / Hydrocarbons, Fluorinated / Antimalarials Language: En Journal: Top Curr Chem (Cham) Year: 2019 Document type: Article Affiliation country: Venezuela Country of publication: Switzerland

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