New fluoroquinolone compounds with endo-nortropine derivatives at C-7 position show antibacterial activity against fluoroquinolone-resistant strains of Staphylococcus aureus.

Salunke, Ramkrushna Ashok; Shukla, Manjulika; Kaul, Grace; Bansal, Baldev Raj; Chopra, Sidharth; Chhibber, Manmohan

Salunke, Ramkrushna Ashok; Shukla, Manjulika; Kaul, Grace; Bansal, Baldev Raj; Chopra, Sidharth; Chhibber, Manmohan.

Affiliation

Salunke RA; School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala, India.
Shukla M; Saurav Chemicals Limited, Derabassi- Mohali, India.
Kaul G; CDRI - Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.
Bansal BR; CDRI - Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.
Chopra S; Saurav Chemicals Limited, Derabassi- Mohali, India.
Chhibber M; CDRI - Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.

Chem Biol Drug Des ; 94(3): 1626-1633, 2019 09.

Article in En | MEDLINE | ID: mdl-30860312

Subject(s)

Anti-Bacterial Agents/chemical synthesis; Bacterial Infections/drug therapy; Fluoroquinolones/chemical synthesis; Nortropanes/chemistry; Amines/chemistry; Anti-Bacterial Agents/pharmacology; Bacteria/drug effects; Drug Evaluation, Preclinical; Drug Resistance, Bacterial; Esters/chemistry; Fluoroquinolones/pharmacology; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship

Key words

N-methylpiperazine; levofloxacin; morpholine; nalidixic acid; piperidine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Infections / Fluoroquinolones / Anti-Bacterial Agents / Nortropanes Language: En Journal: Chem Biol Drug Des Journal subject: BIOQUIMICA / FARMACIA / FARMACOLOGIA Year: 2019 Document type: Article Affiliation country: India Country of publication: United kingdom

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