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Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone.
Delgado, Justine L; Lentz, Sarah R C; Kulkarni, Chaitanya A; Chheda, Pratik R; Held, Hailey A; Hiasa, Hiroshi; Kerns, Robert J.
Affiliation
  • Delgado JL; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Ave., S321 Pharmacy Building, Iowa City, IA, 52242, USA.
  • Lentz SRC; Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
  • Kulkarni CA; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Ave., S321 Pharmacy Building, Iowa City, IA, 52242, USA.
  • Chheda PR; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Ave., S321 Pharmacy Building, Iowa City, IA, 52242, USA.
  • Held HA; Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
  • Hiasa H; Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
  • Kerns RJ; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Ave., S321 Pharmacy Building, Iowa City, IA, 52242, USA. Electronic address: robert-kerns@uiowa.edu.
Eur J Med Chem ; 172: 109-130, 2019 Jun 15.
Article in En | MEDLINE | ID: mdl-30959322
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biphenyl Compounds / DNA Topoisomerases, Type I / Fluoroquinolones / Topoisomerase I Inhibitors Limits: Humans Language: En Journal: Eur J Med Chem Year: 2019 Document type: Article Affiliation country: United States Country of publication: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biphenyl Compounds / DNA Topoisomerases, Type I / Fluoroquinolones / Topoisomerase I Inhibitors Limits: Humans Language: En Journal: Eur J Med Chem Year: 2019 Document type: Article Affiliation country: United States Country of publication: France