1,2,4-Oxadiazole-5-ones as analogues of tamoxifen: synthesis and biological evaluation.

Chiacchio, Maria A; Legnani, Laura; Campisi, Agata; Paola, Bottino; Giuseppe, Lanza; Iannazzo, Daniela; Veltri, Lucia; Giofrè, Salvatore; Romeo, Roberto

Chiacchio, Maria A; Legnani, Laura; Campisi, Agata; Paola, Bottino; Giuseppe, Lanza; Iannazzo, Daniela; Veltri, Lucia; Giofrè, Salvatore; Romeo, Roberto.

Affiliation

Chiacchio MA; Dipartimento di Scienze del Farmaco, Università di Catania, Viale A. Doria 6, 95125 Catania, Italy. agcampisi@gmail.com.

Org Biomol Chem ; 17(19): 4892-4905, 2019 05 15.

Article in En | MEDLINE | ID: mdl-31041982

Subject(s)

Antineoplastic Agents, Hormonal/chemical synthesis; Antineoplastic Agents, Hormonal/pharmacology; Oxadiazoles/chemical synthesis; Oxadiazoles/pharmacology; Tamoxifen/analogs & derivatives; Antineoplastic Agents, Hormonal/chemistry; Cell Proliferation/drug effects; Cell Survival/drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Hydrophobic and Hydrophilic Interactions; MCF-7 Cells; Molecular Structure; Oxadiazoles/chemistry; Quantum Theory; Structure-Activity Relationship; Tamoxifen/chemistry; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Tamoxifen / Antineoplastic Agents, Hormonal Type of study: Guideline Limits: Female / Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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