To Cure or Not to Cure: Consequences of Immunological Interactions in CML Treatment.

César Fassoni, Artur; Roeder, Ingo; Glauche, Ingmar

César Fassoni, Artur; Roeder, Ingo; Glauche, Ingmar.

Affiliation

César Fassoni A; Instituto de Matemática e Computação, Universidade Federal de Itajubá, Itajubá, Brazil. fassoni@unifei.edu.br.
Roeder I; Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Glauche I; National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.

Bull Math Biol ; 81(7): 2345-2395, 2019 07.

Article in En | MEDLINE | ID: mdl-31044338

Subject(s)

Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology; Models, Immunological; Antineoplastic Agents/therapeutic use; Computer Simulation; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology; Linear Models; Mathematical Concepts; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/immunology; Neoplastic Stem Cells/pathology; Protein Kinase Inhibitors/therapeutic use; Remission Induction; Systems Biology; Tumor Burden/drug effects; Tumor Burden/immunology

Key words

Bifurcations; Chronic myeloid leukemia; Immunological control; Mathematical modeling; Ordinary differential equations; Treatment-free remission

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Models, Immunological Type of study: Prognostic_studies / Qualitative_research Limits: Humans Language: En Journal: Bull Math Biol Year: 2019 Document type: Article Affiliation country: Brazil Country of publication: United States

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