Effect of L-threo-3,4-dihydroxyphenylserine (L-DOPS), an immediate precursor of norepinephrine, on the cerebral blood flow in rats.
Jpn J Pharmacol
; 43(1): 91-3, 1987 Jan.
Article
in En
| MEDLINE
| ID: mdl-3106684
L-threo-3,4-Dihydroxyphenylserine (L-DOPS), a norepinephrine (NE) precursor, 3 mg/kg, i.v., increased the cerebral blood flow (CBF) in both the striatum and hippocampus as well as the mean arterial blood pressure (MABP) in urethane-anesthetized rats, as NE infusion did. The L-DOPS induced increase in CBF was inhibited by benserazide (3 mg/kg/hour), a peripheral aromatic L-amino acid decarboxylase inhibitor, and propranolol (3 mg/kg, i.p.), a beta-adrenoceptor blocker as well. These results suggest that the effects of L-DOPS may be attributed to the action of NE formed from L-DOPS, and the action may be mediated by stimulation of beta-adrenoceptor.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Serine
/
Norepinephrine
/
Cerebrovascular Circulation
/
Droxidopa
Limits:
Animals
Language:
En
Journal:
Jpn J Pharmacol
Year:
1987
Document type:
Article
Country of publication:
Japan