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Analysis of 8q24.21 miRNA cluster expression and copy number variation in gastric cancer.
Anauate, Ana C; Leal, Mariana F; Wisnieski, Fernanda; Santos, Leonardo C; Gigek, Carolina O; Chen, Elizabeth S; Calcagno, Danielle Q; Assumpção, Paulo P; Demachki, Sâmia; Arasaki, Carlos H; Artigiani, Ricardo; Rasmussen, Lucas T; Payão, Spencer M; Burbano, Rommel R; C Smith, Marília A.
Affiliation
  • Anauate AC; Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, 04023-900, Brazil.
  • Leal MF; Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, 04023-900, Brazil.
  • Wisnieski F; Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, 04023-900, Brazil.
  • Santos LC; Disciplina de Gastroenterologia, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, 04040-002, Brazil.
  • Gigek CO; Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, 04023-900, Brazil.
  • Chen ES; Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, 04023-900, Brazil.
  • Calcagno DQ; Disciplina de Gastroenterologia Cirúrgica, Departamento de Cirurgia, Universidade Federal de São Paulo, São Paulo, 04024-002, Brazil.
  • Assumpção PP; Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, 04023-900, Brazil.
  • Demachki S; Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, 66073-000, Brazil.
  • Arasaki CH; Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, 66073-000, Brazil.
  • Artigiani R; Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, 66073-000, Brazil.
  • Rasmussen LT; Disciplina de Gastroenterologia Cirúrgica, Departamento de Cirurgia, Universidade Federal de São Paulo, São Paulo, 04024-002, Brazil.
  • Payão SM; Departamento de Patologia, Universidade Federal de São Paulo, São Paulo, 04023-062, Brazil.
  • Burbano RR; Departamento de Genética e Biologia Molecular, Faculdade de Medicina de Marília, Marília, 17519-050, Brazil.
  • C Smith MA; Departamento de Genética e Biologia Molecular, Faculdade de Medicina de Marília, Marília, 17519-050, Brazil.
Future Med Chem ; 11(9): 947-958, 2019 05.
Article in En | MEDLINE | ID: mdl-31141411
Aim: To analyze gene expression and copy number of five miRNAs (miR-1204, miR-1205, miR-1206, miR-1207 and miR-1208) localized in this chromosome region in gastric cancer (GC). Materials & methods: 65 paired neoplastic and non-neoplastic specimens collected from GC patients and 20 non-neoplastic gastric tissues from cancer-free individuals were included in this study. The expression levels of the five miRNAs were accessed by real time qPCR and were correlated. Results: MiR-1207-3p, miR-1205, miR-1207-5p and miR-1208 were upregulated in approximately 50% of GC tumors in relation to those of adjacent non-neoplastic tissues. MiR-1205 expression was associated with gain of gene copies and was upregulated in adjacent non-neoplastic samples relative to external controls. Conclusion: The coexpression of the 8q24 miRNAs indicated the role of miR-1205 in the initiation of gastric cancer development.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Gene Expression Regulation, Neoplastic / MicroRNAs Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Future Med Chem Year: 2019 Document type: Article Affiliation country: Brazil Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Gene Expression Regulation, Neoplastic / MicroRNAs Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Future Med Chem Year: 2019 Document type: Article Affiliation country: Brazil Country of publication: United kingdom