Organoantimony(III) halide complexes with azastibocine framework as potential antitumor agents: Correlation between cytotoxic activity and NâSb inter-coordination.

Lei, Jian; Liu, Yongping; Ou, Yingcan; Au, Chak-Tong; Chen, Yi; Yin, Shuang-Feng

Organoantimony(III) halide complexes with azastibocine framework as potential antitumor agents: Correlation between cytotoxic activity and NâSb inter-coordination.

Lei, Jian; Liu, Yongping; Ou, Yingcan; Au, Chak-Tong; Chen, Yi; Yin, Shuang-Feng.

Affiliation

Lei J; School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, PR China; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China.
Liu Y; School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, PR China.
Ou Y; School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, PR China.
Au CT; College of Chemistry and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, 411104, PR China.
Chen Y; School of Medicine, Hunan University of Chinese Medicine, Changsha, 410208, PR China; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China. Electronic address: cscy1975@163.com.
Yin SF; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China. Electronic address: sf_yin@hnu.edu.cn.

Eur J Med Chem ; 177: 350-361, 2019 Sep 01.

Article in En | MEDLINE | ID: mdl-31158749

Subject(s)

Antimony/chemistry; Antineoplastic Agents/pharmacology; Coordination Complexes/pharmacology; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Antineoplastic Agents/toxicity; Cell Line, Tumor; Coordination Complexes/chemical synthesis; Coordination Complexes/chemistry; Coordination Complexes/toxicity; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; L-Lactate Dehydrogenase/metabolism; Molecular Structure; Necrosis/chemically induced; Reactive Oxygen Species/metabolism; S Phase Cell Cycle Checkpoints/drug effects; Structure-Activity Relationship

Key words

Cytotoxic activity; Necrosis; Organoantimony(III) complex; Reactive oxygen species; Structure-activity relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coordination Complexes / Antimony / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2019 Document type: Article Country of publication: France

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