Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation.

Chen, Yufei; Ernst, Patricia

Chen, Yufei; Ernst, Patricia.

Affiliation

Chen Y; a Department of Pediatrics , Section of Hematology/Oncology/Bone Marrow Transplant, University of Colorado/Anschutz Medical Campus , Aurora , CO , USA.
Ernst P; a Department of Pediatrics , Section of Hematology/Oncology/Bone Marrow Transplant, University of Colorado/Anschutz Medical Campus , Aurora , CO , USA.

Cell Cycle ; 18(14): 1525-1531, 2019 07.

Article in En | MEDLINE | ID: mdl-31161857

Subject(s)

Hematopoietic Stem Cells/metabolism; Histone-Lysine N-Methyltransferase/genetics; Histone-Lysine N-Methyltransferase/metabolism; Leukemia, Myeloid, Acute/genetics; Myeloid-Lymphoid Leukemia Protein/genetics; Myeloid-Lymphoid Leukemia Protein/metabolism; Oncogene Proteins, Fusion/metabolism; Animals; Antineoplastic Agents/pharmacology; Carcinogenesis/genetics; Carcinogenesis/metabolism; Female; Gene Expression Regulation, Leukemic; HEK293 Cells; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute/metabolism; MDS1 and EVI1 Complex Locus Protein/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oncogene Proteins, Fusion/genetics; Tamoxifen/analogs & derivatives; Tamoxifen/pharmacology

Key words

AML; H3K4; KMT2A; MLL; MLL1; histone methyltransferase; leukemia

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Leukemia, Myeloid, Acute / Oncogene Proteins, Fusion / Histone-Lysine N-Methyltransferase / Myeloid-Lymphoid Leukemia Protein Limits: Animals / Female / Humans Language: En Journal: Cell Cycle Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States

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