Differences in CYP3A genotypes of a liver transplant recipient and the donor liver graft and adjustment of tacrolimus dose.

Berger, Florine A; Mulder, Midas B; Ten Bosch-Dijksman, Willemijn; van Schaik, Ron H N; Coenen, Sandra; de Winter, Brenda C M

Berger, Florine A; Mulder, Midas B; Ten Bosch-Dijksman, Willemijn; van Schaik, Ron H N; Coenen, Sandra; de Winter, Brenda C M.

Affiliation

Berger FA; Department of Hospital Pharmacy, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Mulder MB; Department of Hospital Pharmacy, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Ten Bosch-Dijksman W; Department of Hospital Pharmacy, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
van Schaik RHN; Department of Clinical Chemistry, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Coenen S; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
de Winter BCM; Department of Hospital Pharmacy, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

Br J Clin Pharmacol ; 85(8): 1852-1854, 2019 08.

Article in En | MEDLINE | ID: mdl-31190414

Subject(s)

Allografts/metabolism; Cytochrome P-450 CYP3A/genetics; Immunosuppressive Agents/administration & dosage; Liver/metabolism; Tacrolimus/administration & dosage; Adult; Alleles; Cytochrome P-450 CYP3A/metabolism; Dose-Response Relationship, Drug; Female; Genotyping Techniques; Graft Rejection/immunology; Graft Rejection/prevention & control; Humans; Immunosuppressive Agents/pharmacokinetics; Liver Transplantation/adverse effects; Polymorphism, Single Nucleotide; Tacrolimus/pharmacokinetics; Transplant Recipients

Key words

CYP3A5 polymorphism; liver transplantation; pharmacogenetics; tacrolimus; therapeutic drug monitoring

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tacrolimus / Cytochrome P-450 CYP3A / Allografts / Immunosuppressive Agents / Liver Type of study: Prognostic_studies Limits: Adult / Female / Humans Language: En Journal: Br J Clin Pharmacol Year: 2019 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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