Delivery of siRNA therapeutics using cowpea chlorotic mottle virus-like particles.
Biomater Sci
; 7(8): 3138-3142, 2019 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-31257379
While highly promising in medicine, gene therapy requires delivery agents to protect and target nucleic acid therapeutics. We developed a plant viral siRNA delivery platform making use of self-assembling cowpea chlorotic mottle virus (CCMV). CCMV was loaded with siRNAs targeting GFP or FOXA1; to further enhance cell uptake and intracellular trafficking, resulting in more efficient gene knockdown, we appended CCMV with a cell penetrating peptide (CPP), specifically M-lycotoxin peptide L17E.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Carriers
/
Genetic Therapy
/
Bromovirus
/
RNA, Small Interfering
Limits:
Humans
Language:
En
Journal:
Biomater Sci
Year:
2019
Document type:
Article
Affiliation country:
United States
Country of publication:
United kingdom