Akt and Notch pathways mediate polyhexamethylene guanidine phosphate-induced epithelial-mesenchymal transition via ZEB2.

Jeong, Mi Ho; Kim, Ha Ryong; Park, Yong Joo; Chung, Kyu Hyuck

Jeong, Mi Ho; Kim, Ha Ryong; Park, Yong Joo; Chung, Kyu Hyuck.

Affiliation

Jeong MH; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Republic of Korea.
Kim HR; College of Pharmacy, Daegu Catholic University, Gyeongsan, Gyeongsangbuk-do 38430, Republic of Korea.
Park YJ; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Republic of Korea. Electronic address: pyj084@skku.edu.
Chung KH; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Republic of Korea. Electronic address: khchung@skku.edu.

Toxicol Appl Pharmacol ; 380: 114691, 2019 10 01.

Article in En | MEDLINE | ID: mdl-31348943

Subject(s)

Disinfectants/toxicity; Epithelial-Mesenchymal Transition/drug effects; Guanidines/toxicity; Proto-Oncogene Proteins c-akt/metabolism; Pulmonary Fibrosis/metabolism; Receptors, Notch/metabolism; Zinc Finger E-box Binding Homeobox 2/metabolism; A549 Cells; Animals; Humans; Lung/drug effects; Lung/metabolism; Lung/pathology; Male; Mice, Inbred C57BL; Proto-Oncogene Proteins c-akt/genetics; Pulmonary Fibrosis/genetics; Pulmonary Fibrosis/pathology; Receptors, Notch/genetics; Signal Transduction/drug effects; Zinc Finger E-box Binding Homeobox 2/genetics

Key words

Akt; Epithelial-mesenchymal transition; Notch; PHMG-p; ZEB2

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Fibrosis / Disinfectants / Proto-Oncogene Proteins c-akt / Receptors, Notch / Epithelial-Mesenchymal Transition / Zinc Finger E-box Binding Homeobox 2 / Guanidines Limits: Animals / Humans / Male Language: En Journal: Toxicol Appl Pharmacol Year: 2019 Document type: Article Country of publication: United States

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