The ICP0 Protein of Herpes Simplex Virus 1 (HSV-1) Downregulates Major Autophagy Adaptor Proteins Sequestosome 1 and Optineurin during the Early Stages of HSV-1 Infection.

Waisner, Hope; Kalamvoki, Maria

Waisner, Hope; Kalamvoki, Maria.

Affiliation

Waisner H; Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Kalamvoki M; Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA mkalamvoki@kumc.edu.

J Virol ; 93(21)2019 11 01.

Article in En | MEDLINE | ID: mdl-31375597

Subject(s)

Autophagy; Cell Cycle Proteins/antagonists & inhibitors; Herpes Simplex/virology; Herpesvirus 1, Human/physiology; Host-Pathogen Interactions; Immediate-Early Proteins/metabolism; Sequestosome-1 Protein/antagonists & inhibitors; Ubiquitin-Protein Ligases/metabolism; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Down-Regulation; Herpes Simplex/genetics; Herpes Simplex/metabolism; Humans; Immediate-Early Proteins/genetics; Immunity, Innate; Membrane Transport Proteins/genetics; Membrane Transport Proteins/metabolism; Mitophagy; Phagosomes; Proteasome Endopeptidase Complex/metabolism; Sequestosome-1 Protein/genetics; Sequestosome-1 Protein/metabolism; Ubiquitin-Protein Ligases/genetics

Key words

HSV-1; ICP0; autophagy; mitophagy; optineurin (OPTN); p62/SQSTM1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Immediate-Early Proteins / Herpesvirus 1, Human / Cell Cycle Proteins / Ubiquitin-Protein Ligases / Host-Pathogen Interactions / Sequestosome-1 Protein / Herpes Simplex Limits: Humans Language: En Journal: J Virol Year: 2019 Document type: Article Affiliation country: United States

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