Ginkgetin attenuates cerebral ischemia-reperfusion induced autophagy and cell death via modulation of the NF-&#954;B/p53 signaling pathway.

Pan, Jianqing; Li, Xiang; Guo, Fei; Yang, Zhigang; Zhang, Lingling; Yang, Chunshui

Ginkgetin attenuates cerebral ischemia-reperfusion induced autophagy and cell death via modulation of the NF-κB/p53 signaling pathway.

Pan, Jianqing; Li, Xiang; Guo, Fei; Yang, Zhigang; Zhang, Lingling; Yang, Chunshui.

Affiliation

Pan J; Department of Neurology, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen City 518052, P.R. China.
Li X; Department of Neurology, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen City 518052, P.R. China.
Guo F; Department of Neurology, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen City 518052, P.R. China.
Yang Z; Department of Neurology, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen City 518052, P.R. China.
Zhang L; Department of Neurology, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen City 518052, P.R. China.
Yang C; Department of Neurology, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen City 518052, P.R. China yangzyi@126.com.

Biosci Rep ; 39(9)2019 09 30.

Article in En | MEDLINE | ID: mdl-31420372

Subject(s)

Biflavonoids/pharmacology; Brain Ischemia/drug therapy; Reperfusion Injury/drug therapy; Tumor Suppressor Protein p53/genetics; Adenine/analogs & derivatives; Adenine/pharmacology; Animals; Apoptosis/drug effects; Autophagy/drug effects; Benzothiazoles/pharmacology; Brain Ischemia/genetics; Brain Ischemia/pathology; Cell Death/drug effects; Humans; NF-kappa B/antagonists & inhibitors; NF-kappa B/genetics; Neurons/drug effects; Peptides/pharmacology; Rats; Reperfusion Injury/genetics; Reperfusion Injury/pathology; Signal Transduction/drug effects; Toluene/analogs & derivatives; Toluene/pharmacology; Tumor Suppressor Protein p53/antagonists & inhibitors

Key words

NF-κB; autophagy; ginkgetin; ischemia/reperfusion (I/R); p53

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reperfusion Injury / Brain Ischemia / Tumor Suppressor Protein p53 / Biflavonoids Limits: Animals / Humans Language: En Journal: Biosci Rep Year: 2019 Document type: Article Country of publication: United kingdom

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