Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury.

Guo, Shaowei; Perets, Nisim; Betzer, Oshra; Ben-Shaul, Shahar; Sheinin, Anton; Michaelevski, Izhak; Popovtzer, Rachela; Offen, Daniel; Levenberg, Shulamit

Guo, Shaowei; Perets, Nisim; Betzer, Oshra; Ben-Shaul, Shahar; Sheinin, Anton; Michaelevski, Izhak; Popovtzer, Rachela; Offen, Daniel; Levenberg, Shulamit.

Affiliation

Guo S; Department of Biomedical Engineering , Technion-Israel Institute of Technology , Haifa 3200003 , Israel.
Perets N; The First Affiliated Hospital , Shantou University Medical College , Shantou 515041 , China.
Ben-Shaul S; Faculty of Engineering and the Institute of Nanotechnology & Advanced Materials , Bar-Ilan University , Ramat Gan 5290002 , Israel.
Sheinin A; Department of Biomedical Engineering , Technion-Israel Institute of Technology , Haifa 3200003 , Israel.
Popovtzer R; Department of Molecular Biology , Ariel University , Ariel 40700 , Israel.
Offen D; Faculty of Engineering and the Institute of Nanotechnology & Advanced Materials , Bar-Ilan University , Ramat Gan 5290002 , Israel.

ACS Nano ; 13(9): 10015-10028, 2019 09 24.

Article in En | MEDLINE | ID: mdl-31454225

Subject(s)

Exosomes/transplantation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells/metabolism; PTEN Phosphohydrolase/metabolism; RNA, Small Interfering/metabolism; Recovery of Function; Spinal Cord Injuries/physiopathology; Spinal Cord Injuries/therapy; Administration, Intranasal; Animals; Axons/pathology; Blood-Brain Barrier/pathology; Chemotaxis; Electrophysiological Phenomena; Exosomes/ultrastructure; Female; Ganglia, Spinal/pathology; Gold/chemistry; Humans; Magnetic Resonance Imaging; Motor Activity; Nanoparticles/chemistry; Nanoparticles/ultrastructure; Neurons/pathology; Rats, Sprague-Dawley; Spinal Cord/pathology

Key words

PTEN siRNA; complete spinal cord injury; exosome; functional recovery; intranasal; targeted delivery

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord Injuries / Recovery of Function / RNA, Small Interfering / Mesenchymal Stem Cell Transplantation / PTEN Phosphohydrolase / Exosomes / Mesenchymal Stem Cells Limits: Animals / Female / Humans Language: En Journal: ACS Nano Year: 2019 Document type: Article Affiliation country: Israel

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google