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Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair.
Ruetz, Markus; Campanello, Gregory C; Purchal, Meredith; Shen, Hongying; McDevitt, Liam; Gouda, Harsha; Wakabayashi, Shoko; Zhu, Junhao; Rubin, Eric J; Warncke, Kurt; Mootha, Vamsi K; Koutmos, Markos; Banerjee, Ruma.
Affiliation
  • Ruetz M; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
  • Campanello GC; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
  • Purchal M; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
  • Shen H; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • McDevitt L; Broad Institute, Cambridge, MA 02142, USA.
  • Gouda H; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
  • Wakabayashi S; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
  • Zhu J; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Cambridge, MA 02115, USA.
  • Rubin EJ; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Cambridge, MA 02115, USA.
  • Warncke K; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Cambridge, MA 02115, USA.
  • Mootha VK; Department of Physics, Emory University, Atlanta, GA 30322, USA.
  • Koutmos M; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Banerjee R; Broad Institute, Cambridge, MA 02142, USA.
Science ; 366(6465): 589-593, 2019 11 01.
Article in En | MEDLINE | ID: mdl-31672889
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Succinates / Coenzyme A / Methylmalonyl-CoA Mutase / Mycobacterium tuberculosis Limits: Humans Language: En Journal: Science Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Succinates / Coenzyme A / Methylmalonyl-CoA Mutase / Mycobacterium tuberculosis Limits: Humans Language: En Journal: Science Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States