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Upregulation of p53 through induction of MDM2 degradation: Amino acid prodrugs of anthraquinone analogs.
Anifowose, Abiodun; Yuan, Zhengnan; Yang, Xiaoxiao; Pan, Zhixiang; Zheng, Yueqin; Zhang, Zhongwei; Wang, Binghe.
Affiliation
  • Anifowose A; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, United States.
  • Yuan Z; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, United States.
  • Yang X; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, United States. Electronic address: xyang20@gsu.edu.
  • Pan Z; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, United States.
  • Zheng Y; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, United States.
  • Zhang Z; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, United States.
  • Wang B; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, United States. Electronic address: wang@gsu.edu.
Bioorg Med Chem Lett ; 30(2): 126786, 2020 01 15.
Article in En | MEDLINE | ID: mdl-31753697
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Tumor Suppressor Protein p53 / Anthraquinones / Proto-Oncogene Proteins c-mdm2 / Amino Acids Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Tumor Suppressor Protein p53 / Anthraquinones / Proto-Oncogene Proteins c-mdm2 / Amino Acids Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom