Your browser doesn't support javascript.
loading
Origin of the São Paulo Yellow Fever epidemic of 2017-2018 revealed through molecular epidemiological analysis of fatal cases.
Cunha, Marielton Dos Passos; Duarte-Neto, Amaro Nunes; Pour, Shahab Zaki; Ortiz-Baez, Ayda Susana; Cerný, Jirí; Pereira, Bárbara Brito de Souza; Braconi, Carla Torres; Ho, Yeh-Li; Perondi, Beatriz; Sztajnbok, Jaques; Alves, Venancio Avancini Ferreira; Dolhnikoff, Marisa; Holmes, Edward C; Saldiva, Paulo Hilário Nascimento; Zanotto, Paolo Marinho de Andrade.
Affiliation
  • Cunha MDP; Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil. marieltondospassos@gmail.com.
  • Duarte-Neto AN; Pathology Department, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Pour SZ; Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
  • Ortiz-Baez AS; Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
  • Cerný J; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life & Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia.
  • Pereira BBS; Faculty of Tropical AgriSciences, Czech University of Life Sciences in Prague, Prague, Czech Republic.
  • Braconi CT; Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
  • Ho YL; Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
  • Perondi B; Intensive Care Unit, Division of Clinical Infectious and Parasitic Diseases, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Sztajnbok J; Yellow Fever Crisis Committee, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Alves VAF; Institute of Infectology Emílio Ribas, São Paulo, Brazil.
  • Dolhnikoff M; Pathology Department, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Holmes EC; Pathology Department, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Saldiva PHN; School of Life and Environmental Sciences & Sydney Medical School, The University of Sydney, Sydney, Australia.
  • Zanotto PMA; Pathology Department, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Sci Rep ; 9(1): 20418, 2019 12 31.
Article in En | MEDLINE | ID: mdl-31892699
The largest outbreak of yellow fever of the 21st century in the Americas began in 2016, with intense circulation in the southeastern states of Brazil, particularly in sylvatic environments near densely populated areas including the metropolitan region of São Paulo city (MRSP) during 2017-2018. Herein, we describe the origin and molecular epidemiology of yellow fever virus (YFV) during this outbreak inferred from 36 full genome sequences taken from individuals who died following infection with zoonotic YFV. Our analysis revealed that these deaths were due to three genetic variants of sylvatic YFV that belong the South American I genotype and that were related to viruses previously isolated in 2017 from other locations in Brazil (Minas Gerais, Espírito Santo, Bahia and Rio de Janeiro states). Each variant represented an independent virus introduction into the MRSP. Phylogeographic and geopositioning analyses suggested that the virus moved around the peri-urban area without detectable human-to-human transmission, and towards the Atlantic rain forest causing human spill-over in nearby cities, yet in the absence of sustained viral transmission in the urban environment.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Yellow Fever / Yellow fever virus / RNA, Viral / Epidemics Limits: Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Brazil Country of publication: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Yellow Fever / Yellow fever virus / RNA, Viral / Epidemics Limits: Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Brazil Country of publication: United kingdom