Repurposing Papaverine as an Antiviral Agent against Influenza Viruses and Paramyxoviruses.

Aggarwal, Megha; Leser, George P; Lamb, Robert A

Aggarwal, Megha; Leser, George P; Lamb, Robert A.

Affiliation

Aggarwal M; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.
Leser GP; Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, USA.
Lamb RA; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.

J Virol ; 94(6)2020 02 28.

Article in En | MEDLINE | ID: mdl-31896588

Subject(s)

Antiviral Agents/pharmacology; Drug Repositioning; Orthomyxoviridae Infections; Orthomyxoviridae/metabolism; Papaverine/pharmacology; Paramyxoviridae Infections; Paramyxovirinae/metabolism; Animals; Dogs; Drug Evaluation, Preclinical; HEK293 Cells; Humans; MAP Kinase Signaling System/drug effects; Madin Darby Canine Kidney Cells; Orthomyxoviridae Infections/drug therapy; Orthomyxoviridae Infections/metabolism; Orthomyxoviridae Infections/pathology; Paramyxoviridae Infections/metabolism; Paramyxoviridae Infections/pathology

Key words

ERK; MAPK; MEK; cAMP; influenza virus; inhibitors; nuclear export; papaverine; paramyxovirus; phosphodiesterase; vRNP

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Orthomyxoviridae / Papaverine / Paramyxovirinae / Paramyxoviridae Infections / Orthomyxoviridae Infections / Drug Repositioning Limits: Animals / Humans Language: En Journal: J Virol Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States

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