Fat Mass and Obesity-Associated (FTO) Stimulates Osteogenic Differentiation of C3H10T1/2 Cells by Inducing Mild Endoplasmic Reticulum Stress via a Positive Feedback Loop with p-AMPK.

Son, Hyo-Eun; Min, Hyeon-Young; Kim, Eun-Jung; Jang, Won-Gu

Son, Hyo-Eun; Min, Hyeon-Young; Kim, Eun-Jung; Jang, Won-Gu.

Affiliation

Son HE; Department of Biotechnology, School of Engineering, Daegu University, Gyeongsan 38453, Korea.
Min HY; Research Institute of AntiAging, Daegu University, Gyeongsan 38453, Korea.
Kim EJ; Department of Biotechnology, School of Engineering, Daegu University, Gyeongsan 38453, Korea.
Jang WG; Research Institute of AntiAging, Daegu University, Gyeongsan 38453, Korea.

Mol Cells ; 43(1): 58-65, 2020 Jan 31.

Article in En | MEDLINE | ID: mdl-31940720

Subject(s)

Alpha-Ketoglutarate-Dependent Dioxygenase FTO/metabolism; Obesity/metabolism; AMP-Activated Protein Kinase Kinases; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics; Animals; Bone Morphogenetic Protein 2/metabolism; Cell Differentiation; Cell Line; Core Binding Factor Alpha 1 Subunit/genetics; Endoplasmic Reticulum Stress; Feedback, Physiological; Gene Expression Regulation; Homeodomain Proteins/genetics; Humans; Mice; Osteogenesis; Phosphorylation; Protein Kinases/metabolism; RNA, Small Interfering/genetics

Key words

C3H10T1/2 cells; adenosine monophosphate-activated protein kinase; endoplasmic reticulum stress; fat mass and obesity-associated; osteoblast

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Obesity Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Mol Cells Journal subject: BIOLOGIA MOLECULAR Year: 2020 Document type: Article Country of publication:

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