Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia.

Li, Jing; Zhao, Runtian; Jiang, Yuhan; Xu, Yi; Zhao, Huan; Lyu, Xiaoling; Wu, Tao

Li, Jing; Zhao, Runtian; Jiang, Yuhan; Xu, Yi; Zhao, Huan; Lyu, Xiaoling; Wu, Tao.

Affiliation

Li J; State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China. lxling@tust.edu.cn.

Food Funct ; 11(2): 1572-1584, 2020 Feb 26.

Article in En | MEDLINE | ID: mdl-32003387

Subject(s)

Amyloid beta-Protein Precursor/metabolism; Anthocyanins/pharmacology; Cognitive Dysfunction/metabolism; Presenilin-1/metabolism; Vaccinium myrtillus; Adaptor Proteins, Signal Transducing/metabolism; Alzheimer Disease/metabolism; Amyloid beta-Protein Precursor/genetics; Animals; Disease Models, Animal; Female; Hippocampus/cytology; Hippocampus/drug effects; Membrane Glycoproteins/metabolism; Mice; Mice, Transgenic; Microglia/drug effects; Plant Extracts/pharmacology; Presenilin-1/genetics; Receptors, Immunologic/metabolism; Sialic Acid Binding Ig-like Lectin 3/metabolism; Signal Transduction/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Protein Precursor / Vaccinium myrtillus / Presenilin-1 / Cognitive Dysfunction / Anthocyanins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Food Funct Year: 2020 Document type: Article Affiliation country: China Country of publication: United kingdom

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