Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.

Li, Qi; Zhai, Yanhui; Man, Xiaxia; Zhang, Sheng; An, Xinglan

Li, Qi; Zhai, Yanhui; Man, Xiaxia; Zhang, Sheng; An, Xinglan.

Affiliation

Li Q; First Hospital, Jilin University, Changchun, Jilin, China.
Zhai Y; First Hospital, Jilin University, Changchun, Jilin, China.
Man X; First Hospital, Jilin University, Changchun, Jilin, China.
Zhang S; First Hospital, Jilin University, Changchun, Jilin, China.
An X; First Hospital, Jilin University, Changchun, Jilin, China.

Cell Reprogram ; 22(2): 82-89, 2020 04.

Article in En | MEDLINE | ID: mdl-32125888

Subject(s)

DNA Modification Methylases/antagonists & inhibitors; Mesenchymal Stem Cells/cytology; Mesenchymal Stem Cells/drug effects; Nanog Homeobox Protein/drug effects; Octamer Transcription Factor-3/drug effects; Phthalimides/pharmacology; Tryptophan/analogs & derivatives; Animals; Apoptosis/drug effects; Bone Marrow Cells/metabolism; Cell Proliferation/drug effects; Cells, Cultured; Cellular Senescence/drug effects; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation/drug effects; Nanog Homeobox Protein/metabolism; Octamer Transcription Factor-3/metabolism; Real-Time Polymerase Chain Reaction; Swine; Tryptophan/pharmacology

Key words

RG108; apoptosis; pluripotency; porcine bone marrow mesenchymal stem cells; senescence

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalimides / Tryptophan / DNA Modification Methylases / Octamer Transcription Factor-3 / Mesenchymal Stem Cells / Nanog Homeobox Protein Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Reprogram Year: 2020 Document type: Article Affiliation country: China Country of publication: United States

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