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[Incidence and impact of venous thrombosis in the diagnosis and therapeutic management of ovarian cancer]. / Incidence et impact de la maladie thrombo-embolique sur la prise en charge du cancer de l'ovaire.
Achen, G; Dolivet, E; Turck, M; Fauvet, R.
Affiliation
  • Achen G; Service de gynécologie-obstétrique et médecine de la reproduction, centre hospitalo-universitaire de Caen, bâtiment FEH, avenue de la Côte de Nacre, 14000 Caen, France. Electronic address: guillaume.achen@gmail.com.
  • Dolivet E; Service de gynécologie-obstétrique et médecine de la reproduction, centre hospitalo-universitaire de Caen, bâtiment FEH, avenue de la Côte de Nacre, 14000 Caen, France; Service de chirurgie, centre François Baclesse, 3, avenue du Général Harris, 14000 Caen, France.
  • Turck M; Service de gynécologie-obstétrique et médecine de la reproduction, centre hospitalo-universitaire de Caen, bâtiment FEH, avenue de la Côte de Nacre, 14000 Caen, France.
  • Fauvet R; Service de gynécologie-obstétrique et médecine de la reproduction, centre hospitalo-universitaire de Caen, bâtiment FEH, avenue de la Côte de Nacre, 14000 Caen, France.
Gynecol Obstet Fertil Senol ; 48(6): 506-513, 2020 06.
Article in Fr | MEDLINE | ID: mdl-32173596
OBJECTIVE: Ovarian cancer is a risk factor for venous thromboembolism (VTE), which worsens overall survival. The main objective of our study was to calculate the incidence of VTE in our population. We analyzed VTE impact on diagnosis and management of ovarian cancer. METHODS: We conducted a retrospective, monocentric study in ovarian, fallopian tube and primary peritoneal cancer patients, divided into 2 groups (« Presence of VTE ¼ and « Absence of VTE ¼). A univariate and multivariate analysis of factors associated with VTE was performed, and we compared delays of management in both groups. RESULTS: Among 157 patients included in the study, 22.9% presented a VTE, and 52.8% were asymptomatic. The VTE was diagnosed prior to any treatment in 61.1% of patients and revealed the ovarian cancer in 27.8% of cases. In multivariate analysis, tumor size (OR=1.1, 95% CI: 1-2.21, P=0.012), malnutrition (OR=3.79, 95% CI: 1.16-12,4, P=0.028) and Ddimer level above 1.5µg/mL (OR=13.8, 95% CI 1.2-152.8, P=0.02) were significantly associated with VTE. No significant difference was found between the two groups in diagnostic or therapeutic strategy, as well as in delays of management. CONCLUSION: We report a high incidence of VTE in ovarian cancer, including a lot of asymptomatic events. An early diagnosis with clinical examination and Ddimer level could improve its management and its prognosis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Venous Thrombosis Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Aged / Female / Humans / Middle aged Language: Fr Journal: Gynecol Obstet Fertil Senol Year: 2020 Document type: Article Country of publication: France

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Venous Thrombosis Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Aged / Female / Humans / Middle aged Language: Fr Journal: Gynecol Obstet Fertil Senol Year: 2020 Document type: Article Country of publication: France