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The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin.
Sarkar, Saswata S; Trivedi, Darshan V; Morck, Makenna M; Adhikari, Arjun S; Pasha, Shaik N; Ruppel, Kathleen M; Spudich, James A.
Affiliation
  • Sarkar SS; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Trivedi DV; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Morck MM; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Adhikari AS; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Pasha SN; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Ruppel KM; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Spudich JA; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sci Adv ; 6(14): eaax0069, 2020 04.
Article in En | MEDLINE | ID: mdl-32284968
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiomyopathy, Hypertrophic / Actins / Myosins / Amino Acid Substitution / Alleles / Mutation Limits: Humans Language: En Journal: Sci Adv Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiomyopathy, Hypertrophic / Actins / Myosins / Amino Acid Substitution / Alleles / Mutation Limits: Humans Language: En Journal: Sci Adv Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States