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Short-range regulatory chromatin loops in plants.
Gagliardi, Delfina; Manavella, Pablo A.
Affiliation
  • Gagliardi D; Facultad de Bioquímica y Ciencias Biológicas, Instituto de Agrobiotecnología del Litoral (CONICET-UNL), Cátedra de Biología Celular y Molecular, Universidad Nacional del Litoral, 3000, Santa Fe, Argentina.
  • Manavella PA; Facultad de Bioquímica y Ciencias Biológicas, Instituto de Agrobiotecnología del Litoral (CONICET-UNL), Cátedra de Biología Celular y Molecular, Universidad Nacional del Litoral, 3000, Santa Fe, Argentina.
New Phytol ; 228(2): 466-471, 2020 10.
Article in En | MEDLINE | ID: mdl-32353900
In all eukaryotic organisms, gene expression correlates with the condensation state of the chromatin. Highly packed genome regions, known as heterochromatins, are associated with repressed loci, whereas euchromatic regions represent a relaxed state of the chromatin actively transcribed. However, even in these active regions, associations between chromatin domains dynamically modify genome topology and alter gene expression. Long-range interaction within and between chromosomes determines chromatin domains that help to coordinate transcriptional events. On the other hand, short-range chromatin interactions emerged as dynamic mechanisms regulating the expression of specific loci. Our current capacity to decipher genome topology at high resolution allowed us to identify numerous cases of short-range regulatory chromatin interactions, which are reviewed in this Insight article.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Gene Expression Regulation, Plant Language: En Journal: New Phytol Journal subject: BOTANICA Year: 2020 Document type: Article Affiliation country: Argentina Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Gene Expression Regulation, Plant Language: En Journal: New Phytol Journal subject: BOTANICA Year: 2020 Document type: Article Affiliation country: Argentina Country of publication: United kingdom