A human monoclonal antibody blocking SARS-CoV-2 infection.

Wang, Chunyan; Li, Wentao; Drabek, Dubravka; Okba, Nisreen M A; van Haperen, Rien; Osterhaus, Albert D M E; van Kuppeveld, Frank J M; Haagmans, Bart L; Grosveld, Frank; Bosch, Berend-Jan

Wang, Chunyan; Li, Wentao; Drabek, Dubravka; Okba, Nisreen M A; van Haperen, Rien; Osterhaus, Albert D M E; van Kuppeveld, Frank J M; Haagmans, Bart L; Grosveld, Frank; Bosch, Berend-Jan.

Affiliation

Wang C; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Li W; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Drabek D; Department of Cell Biology, Erasmus Medical Center, Rotterdam, the Netherlands.
Okba NMA; Harbour BioMed, Rotterdam, the Netherlands.
van Haperen R; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.
Osterhaus ADME; Department of Cell Biology, Erasmus Medical Center, Rotterdam, the Netherlands.
van Kuppeveld FJM; Harbour BioMed, Rotterdam, the Netherlands.
Haagmans BL; University of Veterinary Medicine, Hannover, Germany.
Grosveld F; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Bosch BJ; Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.

Nat Commun ; 11(1): 2251, 2020 05 04.

Article in En | MEDLINE | ID: mdl-32366817

Subject(s)

Antibodies, Monoclonal/immunology; Antibodies, Neutralizing/immunology; Antibodies, Viral/immunology; Betacoronavirus/immunology; Coronavirus Infections/immunology; Coronavirus Infections/prevention & control; Pandemics/prevention & control; Pneumonia, Viral/immunology; Pneumonia, Viral/prevention & control; Angiotensin-Converting Enzyme 2; Animals; Antibodies, Monoclonal/pharmacology; Antibodies, Neutralizing/pharmacology; Antibodies, Viral/pharmacology; Antibody Affinity/immunology; Betacoronavirus/chemistry; Betacoronavirus/drug effects; COVID-19; Chlorocebus aethiops; Conserved Sequence; Coronavirus Infections/drug therapy; Coronavirus Infections/virology; Cross Reactions/immunology; Epitopes, B-Lymphocyte/chemistry; Epitopes, B-Lymphocyte/immunology; Humans; In Vitro Techniques; Inhibitory Concentration 50; Models, Molecular; Peptidyl-Dipeptidase A/chemistry; Peptidyl-Dipeptidase A/metabolism; Pneumonia, Viral/drug therapy; Pneumonia, Viral/virology; Protein Binding/drug effects; Protein Domains/immunology; Receptors, Virus/chemistry; Receptors, Virus/metabolism; Severe acute respiratory syndrome-related coronavirus/chemistry; Severe acute respiratory syndrome-related coronavirus/drug effects; Severe acute respiratory syndrome-related coronavirus/immunology; SARS-CoV-2; Spike Glycoprotein, Coronavirus/chemistry; Spike Glycoprotein, Coronavirus/immunology; Vero Cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Antibodies, Neutralizing / Pandemics / Betacoronavirus / Antibodies, Monoclonal / Antibodies, Viral Type of study: Prognostic_studies Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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