Interleukin-23 drives expansion of Thelper 17 cells through epigenetic regulation by signal transducer and activators of transcription 3 in lupus patients.

Lee, Seunghyun; Nakayamada, Shingo; Kubo, Satoshi; Yamagata, Kaoru; Yoshinari, Hiroko; Tanaka, Yoshiya

Lee, Seunghyun; Nakayamada, Shingo; Kubo, Satoshi; Yamagata, Kaoru; Yoshinari, Hiroko; Tanaka, Yoshiya.

Affiliation

Lee S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Nakayamada S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Kubo S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Yamagata K; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Yoshinari H; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Tanaka Y; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.

Rheumatology (Oxford) ; 59(10): 3058-3069, 2020 10 01.

Article in En | MEDLINE | ID: mdl-32375179

Subject(s)

Interleukin-23/pharmacology; Lupus Erythematosus, Systemic/blood; STAT3 Transcription Factor/blood; Th17 Cells/drug effects; Azetidines/pharmacology; CD4-Positive T-Lymphocytes/drug effects; Cell Proliferation/drug effects; Chromatin Immunoprecipitation/methods; Epigenesis, Genetic; Flow Cytometry; Gene Expression; Humans; Interleukin-12/pharmacology; Interleukins/pharmacology; Jumonji Domain-Containing Histone Demethylases/metabolism; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism; Phosphorylation; Purines/pharmacology; Pyrazoles/pharmacology; Real-Time Polymerase Chain Reaction/methods; STAT3 Transcription Factor/drug effects; STAT3 Transcription Factor/metabolism; STAT4 Transcription Factor/metabolism; Signal Transduction; Sulfonamides/pharmacology; Th17 Cells/metabolism

Key words

IL-23; Th17 cells; baricitinib; signal transducer and activator of transcription; systemic lupus erythematosus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: STAT3 Transcription Factor / Interleukin-23 / Th17 Cells / Lupus Erythematosus, Systemic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2020 Document type: Article Country of publication: United kingdom

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