Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor &#945;.

Böckers, Madeleine; Paul, Norbert W; Efferth, Thomas

Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor α.

Böckers, Madeleine; Paul, Norbert W; Efferth, Thomas.

Affiliation

Böckers M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
Paul NW; Institute for History, Theory and Ethics of Medicine, Johannes Gutenberg University Medical Center, Mainz, Germany.
Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany. Electronic address: efferth@uni-mainz.de.

Toxicol Appl Pharmacol ; 399: 115030, 2020 07 15.

Article in En | MEDLINE | ID: mdl-32387340

Subject(s)

Benzhydryl Compounds/pharmacology; Estrogen Receptor alpha/genetics; Gene Expression/drug effects; Phenols/pharmacology; Breast Neoplasms/genetics; Cell Line; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Proliferation/genetics; Down-Regulation/drug effects; Down-Regulation/genetics; Endocrine Disruptors/pharmacology; Estradiol/genetics; Estrogens/genetics; Female; HEK293 Cells; Humans; MCF-7 Cells; Plasticizers/pharmacology; Signal Transduction/drug effects; Signal Transduction/genetics; Up-Regulation/drug effects; Up-Regulation/genetics

Key words

Bisphenol; Estrogen receptor; Microplastic; Next generation sequencing; Tetramethyl bisphenol A

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Benzhydryl Compounds / Gene Expression / Estrogen Receptor alpha Limits: Female / Humans Language: En Journal: Toxicol Appl Pharmacol Year: 2020 Document type: Article Affiliation country: Germany

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