The metabolism of 5-(4-acetamidophenyl)pyrazin-2(1H)-one in rat, dog and cynomolgus monkey.

Ross, D A; Osborne, P M; Pue, M A; Blake, T J; Chenery, R J; Metcalf, R

Ross, D A; Osborne, P M; Pue, M A; Blake, T J; Chenery, R J; Metcalf, R.

Affiliation

Ross DA; Department of Drug Metabolism & Pharmacokinetics, Smith Kline and French Research, Frythe, Welwyn, UK.

Xenobiotica ; 18(12): 1373-87, 1988 Dec.

Article in En | MEDLINE | ID: mdl-3245231

Subject(s)

Pyrazines/metabolism; Animals; Biotransformation; Cytochrome P-450 Enzyme System/metabolism; Dogs; Glucuronates/metabolism; In Vitro Techniques; Liver/drug effects; Liver/metabolism; Macaca fascicularis; Male; Pyrazines/administration & dosage; Pyrazines/pharmacokinetics; Rats; Rats, Inbred Strains; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines Limits: Animals Language: En Journal: Xenobiotica Year: 1988 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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