Simple Addition of Glycine in Trifluoroacetic Acid-Containing Mobile Phases Enhances the Sensitivity of Electrospray Ionization Mass Spectrometry for Biopharmaceutical Characterization.

Mao, Yuan; Kleinberg, Andrew; Zhao, Yunlong; Raidas, Shivkumar; Li, Ning

Mao, Yuan; Kleinberg, Andrew; Zhao, Yunlong; Raidas, Shivkumar; Li, Ning.

Affiliation

Mao Y; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, United States.
Kleinberg A; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, United States.
Zhao Y; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, United States.
Raidas S; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, United States.
Li N; Analytical Chemistry, Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, United States.

Anal Chem ; 92(13): 8691-8696, 2020 07 07.

Article in En | MEDLINE | ID: mdl-32463663

Subject(s)

Antibodies, Monoclonal, Humanized/analysis; Glycine/chemistry; Peptides/analysis; Spectrometry, Mass, Electrospray Ionization/methods; Trifluoroacetic Acid/chemistry; Antibodies, Monoclonal, Humanized/metabolism; Chromatography, High Pressure Liquid/methods; Humans; Peptides/chemistry; Peptides/isolation & purification; Signal-To-Noise Ratio

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Trifluoroacetic Acid / Spectrometry, Mass, Electrospray Ionization / Antibodies, Monoclonal, Humanized / Glycine Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Anal Chem Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States

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