Circular RNA-9119 protects IL-1ß-treated chondrocytes from apoptosis in an osteoarthritis cell model by intercepting the microRNA-26a/PTEN axis.

Chen, Changjian; Yin, Peng; Hu, Shengxiong; Sun, Xuegang; Li, Baowen

Chen, Changjian; Yin, Peng; Hu, Shengxiong; Sun, Xuegang; Li, Baowen.

Affiliation

Chen C; Joint Surgical Department, The Second Hospital of Dalian Medical University, China.
Yin P; Orthopedic Trauma Department, The Second Hospital of Dalian Medical University, China.
Hu S; Orthopedic Surgery, People's Hospital of Huangyuan County, Qinghai Province, China.
Sun X; Orthopedic Surgery, The Second Hospital of Dalian Medical University, China. Electronic address: sunxxxgang@163.com.
Li B; Joint Surgical Department, The Second Hospital of Dalian Medical University, China. Electronic address: Libaowen127@163.com.

Life Sci ; 256: 117924, 2020 Sep 01.

Article in En | MEDLINE | ID: mdl-32522568

Subject(s)

Chondrocytes/metabolism; Interleukin-1beta/metabolism; Osteoarthritis/drug therapy; Protective Agents/metabolism; RNA, Circular/metabolism; 3' Untranslated Regions; Apoptosis/drug effects; Cartilage/metabolism; Cartilage, Articular/metabolism; Cell Line; Chondrocytes/cytology; Down-Regulation; Extracellular Matrix/metabolism; Humans; MicroRNAs/genetics; PTEN Phosphohydrolase/metabolism; Phosphoric Monoester Hydrolases/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Up-Regulation; bcl-2-Associated X Protein/metabolism

Key words

Apoptosis; Circular RNA-9119; Degenerative joint disease; Osteoarthritis; microRNA-26a/PTEN axis

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Chondrocytes / Protective Agents / Interleukin-1beta / RNA, Circular Type of study: Prognostic_studies Limits: Humans Language: En Journal: Life Sci Year: 2020 Document type: Article Affiliation country: China

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google