TGF-ß downregulation overcomes gemcitabine resistance in oral squamous cell carcinoma.

Xuan, Yun-Ze; Jin, Cheng-Ri; Yang, Kang-Juan

Xuan, Yun-Ze; Jin, Cheng-Ri; Yang, Kang-Juan.

Affiliation

Xuan YZ; Department of Dentistry, Affiliated Hospital of Yanbian University, Yanji, Jilin, China.
Jin CR; Department of Dentistry, Affiliated Hospital of Yanbian University, Yanji, Jilin, China.
Yang KJ; Department of Dentistry, Affiliated Hospital of Yanbian University, Yanji, Jilin, China.

Cancer Biomark ; 29(2): 179-187, 2020.

Article in En | MEDLINE | ID: mdl-32741805

Subject(s)

Deoxycytidine/analogs & derivatives; Drug Resistance, Neoplasm/genetics; Mouth Neoplasms/drug therapy; Squamous Cell Carcinoma of Head and Neck/drug therapy; Transforming Growth Factor beta/genetics; Animals; Cell Line, Tumor; Deoxycytidine/pharmacology; Deoxycytidine/therapeutic use; Down-Regulation; Epithelial-Mesenchymal Transition/drug effects; Epithelial-Mesenchymal Transition/genetics; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Mice; Mouth Neoplasms/genetics; Squamous Cell Carcinoma of Head and Neck/genetics; Xenograft Model Antitumor Assays; Gemcitabine

Key words

OSCC; TGF-ß; gemcitabine; lentivirus; resistance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mouth Neoplasms / Transforming Growth Factor beta / Drug Resistance, Neoplasm / Deoxycytidine / Squamous Cell Carcinoma of Head and Neck Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Biomark Journal subject: BIOQUIMICA / NEOPLASIAS Year: 2020 Document type: Article Affiliation country: China

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