Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-&#945; siRNA with PAMAM dendrimers in a murine model.

Bohr, Adam; Tsapis, Nicolas; Foged, Camilla; Andreana, Ilaria; Yang, Mingshi; Fattal, Elias

Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model.

Bohr, Adam; Tsapis, Nicolas; Foged, Camilla; Andreana, Ilaria; Yang, Mingshi; Fattal, Elias.

Affiliation

Bohr A; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Tsapis N; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France.
Foged C; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Andreana I; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France.
Yang M; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Fattal E; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France. Electronic address: elias.fattal@universite-paris-saclay.fr.

Eur J Pharm Biopharm ; 156: 114-120, 2020 Nov.

Article in En | MEDLINE | ID: mdl-32798665

Subject(s)

Dendrimers/administration & dosage; Disease Models, Animal; Drug Delivery Systems/methods; Pneumonia/drug therapy; RNA, Small Interfering/administration & dosage; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Animals; Biocompatible Materials/administration & dosage; Biocompatible Materials/metabolism; Cell Survival/drug effects; Cell Survival/physiology; Dendrimers/metabolism; Dose-Response Relationship, Drug; Female; Lipopolysaccharides/toxicity; Lung/drug effects; Lung/metabolism; Mice; Pneumonia/chemically induced; Pneumonia/metabolism; RAW 264.7 Cells; RNA, Small Interfering/metabolism; Treatment Outcome; Tumor Necrosis Factor-alpha/metabolism

Key words

Dendriplex; Lipopolysaccharide; Lung inflammation; Macrophages; PAMAM dendrimer; TNF-α; siRNA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia / Tumor Necrosis Factor-alpha / Drug Delivery Systems / RNA, Small Interfering / Disease Models, Animal / Dendrimers Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur J Pharm Biopharm Journal subject: FARMACIA / FARMACOLOGIA Year: 2020 Document type: Article Affiliation country: Denmark Country of publication: Netherlands

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